Microbial metabolite succinate activates solitary chemosensory cells in the human sinonasal epithelium.

Elizabeth A Sell,Li Hui Tan,Cailu Lin,John V Bosso,James N Palmer,Nithin D Adappa,Robert J Lee,Michael A Kohanski,Danielle R Reed,Noam A Cohen

International forum of allergy & rhinology（2022）

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摘要

Overall, these findings demonstrate the need for further investigation into the activation of the sinonasal epithelium by succinate in the pathogenesis of CRS.

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关键词

asthma,brush cell,chronic rhinosinusitis,nasal polyps,solitary chemosensory cell,succinate,tuft cell

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