External Validation of the sICOP Score for Early Mortality in Mechanically Ventilated Patients with COVID-19

Background and objectives: The aim of this study was to externally validate the prognostic score for mechanically ventilated patients with novel coronavirus disease 2019 (COVID-19), the sICOP score.Methods: This was a retrospective, multicenter, observational study conducted using the database registry of patients with moderate-to-severe COVID-19 at 66 hospitals in Japan. The data of 146 mechanically ventilated COVID-19 patients were analyzed.Results: The areas under the curve (AUC) of the sICOP score for predicting the 28-day mortality and in-hospital mortality were 0.81 (0.73-0.89) and 0.74 (0.65-0.83), respectively. The AUC of the score was statistically significantly higher than that of the SOFA score for 28-day mortality and in-hospital mortality (28-day mortality; 0.82 [0.73-0.90] vs. 0.58 [0.46-0.70], p < 0.001, in-hospital mortality; 0.75 [0.66-0.84] vs 0.55 [0.44-0.66], p < 0.001).Conclusion: The sICOP score was useful for predicting 28-day mortality with excellent accuracy in mechanically ventilated COVID-19 patients.