Sub-acute and sub-chronic toxicity assessment of the antimicrobial peptide Dermaseptin B2 on biochemical, haematological and histopathological parameters in BALB/c mice and Albino Wistar rats.

Ahmed A Abdille,Shedrack Reuben Kitimu, Mark M Ndubi,Josephine Kimani,Esther N Maina,Wallace Bulimo,Yahaya Gavamukulya,Fred Wamunyokoli

Heliyon（2022）

Cited 0|Views14

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Abstract

The results of this study indicate that short term treatment of Drs B2 could be safe to the animals, however, long-term treatment can have mild effects on the liver parameters and cause an inflammatory response in the spleen.

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Key words

Antimicrobial peptides,Dermaseptin B2,Sub-acute toxicity,Sub-chronic toxicity,Toxicity

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