Analysis and comparison of SARS-CoV-2 variant antibodies and neutralizing activity for 6 months after a booster mRNA vaccine in a healthcare worker population.

Sina Hosseinian,Rafael de Assis,Ghali Khalil,Madeleine K Luu, Aarti Jain,Peter Horvath,Rie Nakajima, Anton M Palma, Anthony Hoang,Eisa Razzak, Nicholas Garcia,Joshua Alger, Mina Kalantari,Emily K Silzel, Algis Jasinskas,Frank Zaldivar, Sebastian D Schubl,Philip L Felgner,Saahir Khan

Research square（2023）

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摘要

In the context of recurrent surges of SARS-CoV-2 infections, our data indicate that breakthrough infections are likely driven by novel variants with different antibody specificity and not by time since last dose of vaccination, indicating that development of vaccinations specific to these novel variants is necessary to prevent future surges of SARS-CoV-2 infections.

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关键词

serology, vaccine, mRNA, healthcare worker (HCW), SARS-CoV-2

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