Noninvasive Classification of Glioma Subtypes Using Multiparametric MRI to Improve Deep Learning.

: Deep learning (DL) methods can noninvasively predict glioma subtypes; however, there is no set paradigm for the selection of network structures and input data, including the image combination method, image processing strategy, type of numeric data, and others. : To compare different combinations of DL frameworks (ResNet, ConvNext, and vision transformer (VIT)), image preprocessing strategies, magnetic resonance imaging (MRI) sequences, and numerical data for increasing the accuracy of DL models for differentiating glioma subtypes prior to surgery. : Our dataset consisted of 211 patients with newly diagnosed gliomas who underwent preoperative MRI with standard and diffusion-weighted imaging methods. Different data combinations were used as input for the three different DL classifiers. : The accuracy of the image preprocessing strategies, including skull stripping, segment addition, and individual treatment of slices, was 5%, 10%, and 12.5% higher, respectively, than that of the other strategies. The accuracy increased by 7.5% and 10% following the addition of ADC and numeric data, respectively. ResNet34 exhibited the best performance, which was 5% and 17.5% higher than that of ConvNext tiny and VIT-base, respectively. : The findings demonstrated that the addition of quantitatively numeric data, ADC images, and effective image preprocessing strategies improved model accuracy for datasets of similar size. The performance of ResNet was superior for small or medium datasets.