Investigating confounding in network-based test-negative design influenza vaccine effectiveness studies-Experience from the DRIVE project.

Anke L Stuurman,Miriam Levi,Philippe Beutels,Hélène Bricout,Alexandre Descamps,Gaël Dos Santos,Ian McGovern,Ainara Mira-Iglesias,Jos Nauta,Laurence Torcel-Pagnon,Jorne Biccler

Influenza and other respiratory viruses（2023）

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摘要

Our study supports a parsimonious approach to confounder adjustment in TND studies, limited to adjusting for age, sex, and calendar time. Practical implications are that necessitating fewer variables lowers the threshold for enrollment of sites in IVE studies and simplifies the pooling of data from different IVE studies or study networks.

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关键词

adjustment,confounders,covariate,influenza vaccine effectiveness,test-negative design

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