Efficient preclinical treatment of cortical T cell acute lymphoblastic leukemia with T lymphocytes secreting anti-CD1a T cell engagers.

Anaïs Jiménez-Reinoso,Néstor Tirado,Alba Martinez-Moreno,Víctor M Díaz,Marina García-Peydró,Oana Hangiu,Laura Díez-Alonso,Ángela Albitre,Petronila Penela,Maria L Toribio,Pablo Menéndez,Luis Álvarez-Vallina,Diego Sánchez Martínez

Journal for immunotherapy of cancer（2022）

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摘要

Our data suggest that CD1a-STAb T cells could be an alternative to CD1a-CAR T cells in coT-ALL patients with aggressive and hyperleukocytic relapses with limited numbers of non-leukemic effector T cells.

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immunotherapy

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