Chloroquinolone Carboxamide Derivatives as New Anti-HSV-1 Promising Drugs.

Mariana Souza,Camilly Pestana Pires de Melo,Letícia Villafranca Faro,Luciane Fragel-Madeira,Viveca Giongo,Paula Alvarez Abreu,Fernanda da Costa Santos Boechat,David de Oliveira Silva,Nathalia Motta de Carvalho Tolentino,Claudio Cesar Cirne-Santos,Caroline de Souza Barros,Helena Carla Castro,Marcos Costa de Souza,Maria Cecília Bastos Vieira de Souza,Izabel Christina Nunes de Palmer Paixão

Current topics in medicinal chemistry（2023）

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摘要

Although the inhibition activities of chloroquinolone carboxamide derivatives were lower than acyclovir, they showed different modes of action in comparison to the drugs currently available. These findings encourage us to continue pre-clinical studies for the development of new anti-HSV-1 agents.

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关键词

Acyclovir,Antiviral drugs,Chloroquinolone carboxamide,HSV-1,Oral bioavailability,Viral protein

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