Clinical Characteristics and the Effect of Timing for Metagenomic Next-Generation Sequencing in Critically Ill Patients with Sepsis.

Dehua He,Ming Liu,Qimin Chen,Ying Liu,Yan Tang,Feng Shen,Difen Wang,Xu Liu

Infection and drug resistance（2022）

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摘要

In critically ill patients with sepsis, the most common sample type for mNGS was BALF, and the positive rate of mNGS is higher than conventional cultures, especially in viruses and fungi. Meanwhile, mNGS can guide clinicians in adjusting antibiotic regimens. Age and the SOFA score on the day of mNGS sampling were independent risk factors for death.

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critical care,metagenomic next-generation sequencing,outcome,sepsis,timing

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