Legionella pneumophila inhibits type I interferon signaling to avoid cell-intrinsic host cell defense
INFECTION AND IMMUNITY(2023)
Abstract
The host type I interferon (IFN) response protects against Legionella pneumophila infections. Other bacterial pathogens inhibit type I IFN-mediated cell signaling; however, the interaction between this signaling pathway and L. pneumophila has not been well described. Here, we demonstrate that L. pneumophila inhibits the IFN-β signaling pathway but does not inhibit IFN-ψ-mediated cell signaling. The addition of IFN-β to L. pneumophila -infected macrophages limited bacterial growth independently of NOS2 and reactive nitrogen species. The type IV secretion system of L. pneumophila is required to inhibit IFN-β-mediated cell signaling. Finally, we show that the inhibition of the IFN-β signaling pathway occurs downstream of STAT1 and STAT2 phosphorylation. In conclusion, our findings describe a novel host cell signaling pathway inhibited by L. pneumophila via its type IV secretion system.
### Competing Interest Statement
The authors have declared no competing interest.
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Key words
Legionella pneumophila,interferons,immune evasion,nitric oxide,secretion systems
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