Glycyrrhizin prevents 3-nitropropionic acid-induced neurotoxicity by downregulating HMGB1/TLR4/NF-κB p65 signaling, and attenuating oxidative stress, inflammation, and apoptosis in rats.
Life sciences（2022）
Abstract
Accordingly, the current study demonstrated a promising neuroprotective effect of Glyc against experimentally induced HD through alleviating deleterious events by diverse mechanisms.
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Key words
3-Nitropropionic acid,Glycyrrhizin,HMGB1/TLR4/NF-κB,Inflammation,Neurotoxicity,Oxidative stress
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