RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD.
Hannelore P Van Eeckhoutte,Chantal Donovan,Richard Y Kim,Thomas M Conlon,Meshal Ansari,Haroon Khan,Ranjith Jayaraman,Nicole G Hansbro,Yves Dondelinger,Tom Delanghe,Allison M Beal,Brad Geddes,John Bertin,Tom Vanden Berghe,Joyceline De Volder,Tania Maes,Peter Vandenabeele,Bart M Vanaudenaerde,Dieter Deforce,Sonja Škevin,Filip Van Nieuwerburgh,Fien M Verhamme,Guy F Joos,Sobia Idrees,Herbert B Schiller,Ali Önder Yildirim,Alen Faiz,Mathieu J M Bertrand,Guy G Brusselle,Philip M Hansbro,Ken R Bracke The European respiratory journal（2022）
摘要
RIPK1 kinase inhibition is protective in experimental models of COPD and may represent a novel promising therapeutic approach.
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关键词
copd,cell death,inflammation,kinase-dependent
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