NLRP3 deficiency decreases alcohol intake controlling anxiety-like behavior via modification of glutamatergic transmission in corticostriatal circuits.
Journal of neuroinflammation(2022)
摘要
Our results demonstrate that NLRP3 deficiency decreases binge alcohol intake and anxiety-like behavior through downregulation of glutamatergic transmission in corticostriatal circuits, which may provide an anti-inflammatory target for treating alcohol use disorders.
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关键词
Alcohol,Glutamatergic transmission,NLRP3 inflammasome,Striatum,Synaptic plasticity
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