Postpartum reversible cerebral vasoconstriction syndrome presenting with reversible splenial lesion

Co-occurrence of postpartum reversible cerebral vasoconstriction syndrome (RCVS) and reversible splenial lesion syndrome (RESLES) is highly rare, and may provide an opportunity in understanding the mechanism of these two rare entities. A 28-year-old female with postpartum psychosis in association with both RCVS and RESLES was reported. The worsening with antipsychotics and the dramatic response to oral nimodipine served as a clue to the diagnosis. RESLES and RCVS may have overlapping pathophysiology. It is possible that RESLES is one of the forms of cerebral edema resulting from RCVS.