Meta‐analysis of age‐related cognitive decline reveals a novel locus for the attention domain and implicates a COVID‐19 related gene for global cognitive function

Alzheimer's & Dementia(2022)

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摘要
rs6559700 was associated with decline of attention. APOE4 was associated with decline of memory and global cognitive decline. TMPRSS11D, a gene involved in the activation of SARS-CoV-2, was implicated in global cognitive decline. Cognitive domain abilities had both unique and shared molecular pathways across the domains.
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关键词
APOE,GWAS,TMPRSS11D,cognitive decline,meta-analysis,neurocognitive domains
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