Revisiting the Role of Immunotherapy for Colorectal Cancer Treatment in Patients with Constitutional Mismatch Repair Deficiency
Journal of Cancer Science and Clinical Therapeutics(2022)
摘要
Patients with constitutional mismatch repair deficiency syndrome (CMMRD) usually develop multiple tumors at a young age. Chemotherapy was previously shown to be less effective in these tumors. Recent reports suggest immunotherapeutic treatment in CMMRD-associated tumors. Here, we present a CMMRD patient, successfully treated with immunotherapy for metastasized colorectal cancer (CRC). A young adolescent male was diagnosed with T2N2M1 cecum carcinoma with liver metastases. He received four initial doses of nivolumab (3 mg/kg) with ipilimumab (1 ml/ kg) every three weeks, followed by 41 doses of nivolumab alone every two weeks. A complete response was achieved; also pathological assessment of removed liver metastases was indicative of a complete response. At the time of writing, 14 months after end of treatment, the CRC had not recurred. Immunotherapeutic treatment resulted in a complete response of the primary CRC and metastases. Immunotherapy as first line treatment should be strongly considered in treatment of CMMRD-associated CRCs.
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关键词
constitutional mismatch repair deficiency,colorectal cancer treatment,colorectal cancer,immunotherapy
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