[Role of the CCL28-CCR10 pathway in monocyte migration in rheumatoid arthritis].

F Cheng,S Y Yang, X X Fang,X Wang,F T Zhao

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences（2022）

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摘要

RA patients had increased CCR10 expression on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages. CCL28 ligation to CCR10 promoted RA monocyte migration through activation of the ERK and PI3K/Akt signaling pathways. The CCL28-CCR10 pathway could participate in monocyte recruitment into RA joints, thereby contributing to synovial inflammation and bone destruction.

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关键词

Chemokine CCL28,Chemokine receptor CCR10,Monocytes,Rheumatoid arthritis

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