Base-catalyzed monofunctionalization of N-alkyl activated azaarenes to construct 2-Iminoderivatives

An efficient and simple synthesis of various N-sulfonylimino quinolines and pyridines had been achieved via monofunctionalization of quinoliniums and pyridiniums, which could regioselectively favor in nucleophilic attack at the C-2 position. This base-promoted methodology has been directly to form the 2-sulfonylimino derivatives with simple available starting materials, metal-free conditions, and high regioselectivity.