Teaching Video NeuroImage: Wernekink Commissure Syndrome
Neurology(2022)
Abstract
A 62-year-old woman presented with sudden-onset staggering gait and dysarthria. Neurologic examination revealed truncal and appendicular ataxia in all limbs and cerebellar dysarthria (Video 1), slight slowing of internal right eye rotation during leftward gaze, and left eye nystagmus on abduction. The deep tendon reflexes were normal. Diffusion-weighted imaging showed a high-signal midline lesion in the right midbrain (Figure). We diagnosed the patient with Wernekink commissure syndrome caused by midbrain infarction. Wernekink commissure syndrome is a rare syndrome of bilateral ataxia and oculomotor dysfunction caused by caudal paramedian midbrain lesions.(1,2) The responsible vessel is considered the inferior paramedian mesencephalic artery, which originates from both the distal basilar artery and proximal posterior cerebral artery or the superior cerebellar artery.(2) This lesion involves the superior cerebellar peduncles, their decussation, and the medial longitudinal fasciculi.(2) Clinicians should consider midbrain lesions in patients with acute-onset bilateral ataxia.
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