Methotrexate and Triptolide regulate Notch signaling pathway by targeting the Nedd4-Numb axis

Qiuyu Wu,Xiangjie Chen,Caixia Qiao,Xinhua Cao,Qian Du,Yukang Yuan,Yibo Zuo,Ying Miao,Zhijin Zheng,Tingting Zhang,Lichao Zang,Xinyu Yang,Weifeng Shi,Zhijun Xie,Yang Xu,Depei Wu,Chengping Wen,Hui Zheng

International Immunopharmacology（2023）

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摘要

•MTX inhibits the Notch signaling pathway.•MTX inhibited the interaction between Nedd4 with Numb.•TPL could activates the Notch signaling pathway.•TPL attenuates MTX-induced inhibition of the Notch signaling pathway.

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关键词

Methotrexate,Triptolide,Notch,Numb,Nedd4

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