Laser interstitial thermal therapy for the treatment of primary and metastatic brain tumors: a systematic review and meta-analysis.

New neurological deficits and post-procedural edema were the most reported adverse events following LITT, albeit mostly transient. This meta-analysis provides the best statistical estimates of progression and survival outcomes based on currently available information. LITT is generally a safe procedure for selected patients, and future well-designed comparative studies on its outcomes versus the current standard-of-care should be performed.