Microenvironment pH modified solid dispersion of Toltrazuril as a new strategy to improve the treatment of experimental Apicomplexan infection

•Drug bioavailability of pHM-SD was improved notably compared with TOL and Baycox®.•Oral administration of the pHM-SD provided better drug bioavailability and safety.•The pHM-SD could effectively reduce E. magna oocysts and kill T. gondii tachyzoites.•The pHM-SD could be a new candidate to improve treatment of Apicomplexan infection.