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Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition

Yue Liu,Abudureyimu Abula,Haonan Xiao,Hangtian Guo,Tinghan Li,Le Zheng,Biqing Chen,Henry C Nguyen,Xiaoyun Ji

Journal of Molecular Biology（2023）

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Abstract
•The crystal structure of hnRNP A2/B1 RRMs dimer in complex with U-shaped conformation of ssDNA has been determined.•hnRNP A2/B1 RRMs homodimerise in solution by binding to pre-generated U-shaped DNA, either in ssDNA or dsDNA.•hnRNP A2/B1 RRMs homodimer induced by U-shaped ssDNA binding in solution exists a “Dimer A2” protein dimer interface.•The dimer interface formed in solution biochemically which depicts a potential functional state of hnRNP A2/B1.
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Key words
hnRNP A2/B1,RRMs domain,crystal structure,homodimerization,U-shaped DNA
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