The optimal regimen, efficacy and safety of tranexamic acid and aminocaproic acid to reduce bleeding for patients after total hip arthroplasty: A systematic review and Bayesian network meta-analysis

Findings: Multivariable Bayesian random effects models was adopted in this network analysis. After evaluating total blood loss, HB drop, transfusion rates and PE/DVT rates, as well as performing subgroup analyses to determine the influence of timing and number of doses. We found that: (1) medium dose (20-40 mg/kg or 1.5–3.0 g) of combined IV/IA TXA was effective enough to control bleeding for patients after THA without increasing risk for PE/DVT. (2) TXA was at least 5 times more potent than EACA. (4) Timing and number of doses had few influences on blood conserving efficacy. (5) Single dose of IA TXA was not recommended.Unlabelled Image