Pharmacokinetics of cefmetazole in plasma, peritoneal fluid, peritoneum, and subcutaneous adipose tissue of patients scheduled for lower gastrointestinal surgery: Dosing considerations based on site-specific pharmacodynamic target attainment

Yuki Kaiki,Hiroki Ohge,Kazuro Ikawa,Shinnosuke Uegami,Yusuke Watadani,Norifumi Shigemoto,Toshinori Hirano,Kosuke Yoshimura,Hiroki Kitagawa,Norifumi Morikawa,Shinya Takahashi

Journal of Infection and Chemotherapy（2022）

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摘要

These findings clarify the PK of CMZ in abdominal tissues and could help decide optimal dosing regimens to treat intra-abdominal infection and prophylaxis of SSI.

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关键词

Cefmetazole,Pharmacokinetics,Pharmacodynamics,ESBL,Carbapenem-sparing,Lower gastrointestinal surgery

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