Arsenic-induced differential inflammatory responses in mouse thymus involves NF-κB/STAT-3 disruption, Treg bias and autophagy activation

Ankur Das,Olivia Chowdhury,Payal Gupta,Nirmal Das,Ankan Mitra,Sourav Ghosh,Sayan Ghosh,Swaimanti Sarkar,Debasish Bandyopadhyay,Sreya Chattopadhyay

Life Sciences（2023）

引用 3|浏览12

暂无评分

摘要

•Arsenic-mediated Nrf2 down-regulation and M1 macrophage activation instigates inflammatory signaling cascades.•Arsenic-induced disruption of NF-κB/STAT-3 interaction confers differential cytokine response.•NF-κB influences arsenic–mediated differentiation of CD4+ T cells into FoxP3+ Treg cells leading to immune-suppression.•Inflammation-associated autophagy activation supports the immune-suppressive activity of T regulatory cells.

查看译文

关键词

As,WHO,IARC,ROS,SOD,CAT,GSH,GSSG,GR,GPx,MΦ,ELISA,IL,Bax,Bcl-2,DCF-DA,Nrf2,Keap1,NF-κB,FoxP3,Co-IP,AVOs

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要