Diastereoselective Synthesis, Characterization, Investigation of Anticancer, Antibacterial Activities, In Silico Approaches and DNA/BSA Binding Affinities of Novel Pyrimidine-Sugar Derivatives

Nuran Kahriman,Vildan Serdaroğlu,Ali Aydın,Burçin Türkmenoğlu,Asu Usta

Journal of Molecular Structure（2023）

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摘要

•Novel pyrimidine-sugar derivatives (β-anomer) were synthesized.•Acetylation had a positive effect on the pharmacological properties.•Acetylation significantly enhanced antiproliferative effect without harming normal cells.•Tetra-O-acetyl derivatives were found to have higher affinity for DNA.•Most of compounds were at least as sensitive as the positive control SCF antibiotic.

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关键词

2-amino-4-aryl-6-pyridopyrimidine,glycosylation,diastereoselectivity,N-β-D-glycosides,anti-proliferative,cytotoxic,antibacterial and DNA/protein binding affinity,in silico

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