Transfer RNA-derived small RNAs (tsRNAs) sequencing revealed a differential expression landscape of tsRNAs between glioblastoma and low-grade glioma

•It is the first time that tsRNAs were investigated in gliomas.•A differential tsRNA expression landscape was observed between glioblastomas (GBMs) and low-grade gliomas (LGs).•Differentially expressed tsRNAs are associated with nucleotide excision repair (NER), Hippo pathways, and cancer-related pathways which might be promising targets for overcoming drug resistance (DR) of GBMs.