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Donepezil-loaded PLGA-b-PEG Nanoparticles Enhance the Learning and Memory Function of Beta-Amyloid Rat Model of Alzheimer's Disease.

Elif Çınar,Sevgi Uğur Mutluay,İpek Baysal,Merve Gültekinoğlu,Kezban Ulubayram,Samiye Yabanoğlu Çiftçi,Banu Cahide Tel,Gülberk Uçar

Noro psikiyatri arsivi（2022）

Cited 2|Views15
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Abstract
Targeting with donepezil-loaded PLGA-b-PEG-NPs increases efficiency, helps to inhibit acetylcholinesterase activity more substantially, improves cognitive decline due to its longer duration of action and destabilizing effect on amyloid fibrils.
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Key words
Alzheimer’s disease,animal model,behavioral test,brain targeting,donepezil,nanoparticle
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