Variation of DNA methylation on the IRX1/2 genes is responsible for the neural differentiation propensity in human induced pluripotent stem cells

Asato Sekiya,Ken Takasawa,Yoshikazu Arai,Shin-Ichi Horike,Hidenori Akutsu,Akihiro Umezawa,Koichiro Nishino

Regenerative Therapy（2022）

引用 2|浏览16

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摘要

•Ability of hiPSCs to differentiate into neural stem cells differs from line to line.•Epigenetic markers to predict NSC differentiation ability of hiPSCs were identified.•DNA methylation of IRX1/2 related to neural differentiation ability in female hiPSCs.•Overexpression of IRX1/2 in undifferentiated hiPSCs impaired neural differentiation.

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关键词

Human iPSCs,Neural stem cells,DNA methylation,Differentiation propensity,Machine learning

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