Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age.

Tyler Reed Bell,Jeremy A Elman,Asad Beck, Christine Fennema-Notestine,Daniel E Gustavson,Donald J Hagler, Amy J Jack,Michael J Lyons,Olivia K Puckett,Rosemary Toomey,Carol E Franz,William S Kremen

Journal of the International Neuropsychological Society : JINS（2022）

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摘要

Lower rostral-middle LC integrity is associated with greater subjective cognitive decline. Although not explained by objective cognitive performance, such a relationship may explain increased AD risk in people with subjective cognitive decline as the LC is an important neural substrate important for higher order cognitive processing, attention, and arousal and one of the first sites of AD pathology.

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关键词

brain stem,cognitive complaints,cognitive impairment,noradrenergic,norepinephrine,subcortical

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