Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines.

Mariaserena Giliberto,Leonardo Miranda Santana,Toril Holien,Kristine Misund,Sigve Nakken,Daniel Vodak,Eivind Hovig,Leonardo A Meza-Zepeda,Eivind Coward,Anders Waage,Kjetil Taskén,Sigrid S Skånland

Frontiers in oncology（2022）

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摘要

Taken together, this study shows that mutational status and signaling protein profiling might be used in further studies to predict drug sensitivities and identify resistance markers in MM.

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关键词

MEK,PI3K,drug response biomarkers,drug sensitivity screening,multiple myeloma,mutations,precision medicine,targeted therapy

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