Front Cover: Synthesis of Unsymmetrical Squaramides as Allosteric GSK‐3β Inhibitors Promoting β‐Catenin‐Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells (ChemMedChem 24/2022)

The Front Cover shows the sustainable approach used to develop new unsymmetrical squaramides acting as allosteric GSK3β inhibitors, promoting TCF-LEF transcription in retinal pigment epithelial ARPE-19 cells. This work highlights how green chemistry coupled with computational and biological studies could be a valuable strategy for developing interesting pharmacological tools, activating neuroprotective pathways, and useful in retinal diseases associated with inflammatory/oxidative damage. More information can be found in the Research Article by Gabriele Carullo, Stefania Butini et al.