Impact of neutrophil extracellular traps on fluid properties, blood flow and complement activation.

Antonia Burmeister,Sabine Vidal-Y-Sy,Xiaobo Liu,Christian Mess,Yuanyuan Wang,Swagata Konwar,Todor Tschongov,Karsten Häffner,Volker Huck,Stefan W Schneider,Christian Gorzelanny

Frontiers in immunology（2022）

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摘要

In conclusion, we found that DNA fibers as the principal component of NETs are sufficient to induce blood aggregation even in the absence of the coagulation system. Moreover, we discovered that complement activation at the endothelial surface promoted NET formation. Our data envisions DNA degradation and complement inhibition as potential therapeutic strategies in NET-induced coagulopathies.

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关键词

DNA,blood rheology,blood viscosity,coagulation,complement,immunothrombosis,neutrophil extracellular traps

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