Chemical composition, antioxidant activity and cytotoxicity of flower extracts from Magnolia grandiflora L. found in southeast Mexico

Some reports state that different structures of M. grandiflora contain bioactive components. Nonetheless, phytochemical studies reported that the extracted essential oils are chemically different and remarkably variable in their qualitative and quantitative compositions. Further studies on the Mexican M. grandiflora needs to be done. Thus, the research aimed to characterize a) the chemical composition, b) the antioxidant activity and c) cytotoxicity effect of two M. grandiflora flower extracts. The chemical composition was evaluated by phytochemical test followed by thin layer chro-matography, UV-Vis and FTIR spectrophotometer analysis. The antioxidant activity of the flower extracts was measured by the free radical-scavenging activity (ABTS) and the stable radical of 2,2-diphenyl-1-picryl-hydrazyl (DPPH) methods, and the cytotoxicity by an Artemia salina bioassay. Water and ethyl flower extracts showed the presence of organic chro-mophores such as flavonoids. Both extracts (ethyl and water) demonstrated antioxidant activity by both ABTS (459.6 +/- 8.5 and 274.2 +/- 5.7 mu mol TE/g, respectively) and DPPH (3210.4 +/- 2.5 and 219.7 +/- 0.9 mu mol TE/g, respectively) methodologies, and non-cytotoxic activity (LC50, mu g/mL) (1285 +/- 14 and 1116 +/- 15, respectively). The water and ethyl extracts of M. gran-diflora flowers found in southeast Mexico are a promissory source of chemical compounds with attributed biological activity according to the presented results.