Synthetic biologics provide a path to target bHLH transcription factors
NATURE BIOTECHNOLOGY(2023)
摘要
The ability to target the majority of human transcription factors remains an as yet unachieved goal in chemical biology and medicine. We developed a modular, synthetic transcriptional repressor platform that recapitulates the DNA-binding properties of native basic helix-loop-helix (bHLH) domains and can block the DNA-binding functions of an important oncogenic transcription factor target, MYC.
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