Clinical Applications of Nano-Hydroxyapatite in Dentistry

Nano-hydroxyapatite (nano-HAp) is a biomaterial which is finding increasing application in dentistry due to its osteogenic properties and biocompatibility. The aim of the present study is to review the clinical applications of nano-HAp in dentistry. A literature search was performed in PubMeD and Scopus. In total, 154 articles were retrieved. Following title and abstract analysis, 122 articles were excluded. Further 6 articles were excluded through full-text analysis. The systematic review was conducted on 26 articles. In 3 studies, nano-HAp was employed for tissue remineralization, 8 studies applied nano-HAp for the treatment of dentin hypersensitivity, 2 studies evaluated the role of nano-HAp in orthodontics, 9 studies applied nano-HAp as a graft material, and 4 studies applied nano-HAp to periodontology and implantology. The available evidence supports the use of nano-HAp in the prevention of caries, as a desensitizing agent in the treatment of dentin hypersensitivity and as a graft material. It should be, however, highlighted that further research appears mandatory in assessing and validating the full potential of nano-HAp in clinical dentistry.