C-sp3-H Bond Functionalization of alpha-Bromo Ketones for the Synthesis of alpha-Keto Thioamides Using Elemental Sulfur

An efficient metal- and additive-free synthesis of alpha-keto thioamides has been developed via sulfur oxidation of the C-sp3-H bond of alpha-bromo ketones with amines. This environmentally friendly strategy made it possible to synthesize a wide series of alpha-keto thioamides with broad functional group tolerance.