A comparison of different methods for the first-in-pediatric dose selection.
Journal of clinical and translational research（2022）
摘要
The study provides an estimate of first-in-pediatric dose by simple methods to initiate pediatric clinical trials. Especially, Salisbury rule is based on body weight and is very simple and works fairly well in children >30 kg body weight and can be even used in clinical settings.
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关键词
Salisbury rule,age-dependent exponents,body weight,dose,whole-body physiologically based pharmacokinetic
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