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Characterization of pathogenic synovial IL-17A-producing CD8+ T cell subsets in collagen-induced arthritis

Song Zhang, Yanbo Zhou, Pu Yang, Shuo Jia, Cheng Peng,Haiqing Hu,Wei Liu

Cellular Immunology（2023）

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Abstract
•Synovial IL-17A-producing CD8+ T cell subsets are present in collagen-induced arthritis.•Synovial Tc17 cells, transitional Tc17.1 cells, and Tc17.1 cells can be defined by the expression of CCR6, IL-23R, CCR10, CXCR3, and CCR4.•Synovial Tc17.1 cells and transitional Tc17.1 cells are more inflammatory than synovial Tc17 cells.
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Key words
Arthritis,Inflammation,Tc17 cells,Interleukin-17A,Interferon-γ
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