Advantages and limitations of 3D organoids and ex vivo tumor tissue culture in personalized medicine for prostate cancer.

A Mickova, M Morong, M Levková, D Kurfúrstová, G Kharaishvili, I Überall, V Student,S- Drapela,K- Soucek, J Bouchal

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti（2022）

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摘要

We have established cultures of both organoids and tissue fragments from PCa patient samples. However, the expression of tumor markers was not recapitulated in organoids. Inconsistent morphology among tissue fragments and low proliferation hampered the interpretation of the drug testing in most cases. Still, these approaches may be promising using tissues from metastatic castration-resistant prostate cancer.

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关键词

Organoids,ex vivo tissue culture,personalized medicine,precision medicine,prostate cancer

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