Pathologic features and differential diagnosis of chronic hepatitis
Diagnostic Histopathology(2023)
摘要
Persistent or relapsing hepatitic liver injury for more than 6 months results in chronic hepatitis, a broad category that includes the most common liver diseases: viral hepatitis, autoimmune hepatitis, drug-induced liver injury, and fatty liver disease, as well as less common inherited metabolic disorders such as Wilson disease and alpha-1-antitrypsin deficiency. Chronic cholestatic liver disease may also progress to advanced fibrosis and can be mistaken for a chronic hepatitis. Histologic features may overlap, especially at an advanced stage, and thus morphologic findings together with the overall clinical context play a critical role in establishing an accurate diagnosis. This review describes pathologic and clinical features of a spectrum of hepatitic liver disease that can cause chronic hepatitis, as well as diagnostic testing used to establish a diagnosis or distinguish among these entities.
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关键词
alpha-1-antitrypsin,autoimmune hepatitis,chronic hepatitis,drug,fatty liver disease,hepatitis B,hepatitis C,steatohepatitis,Wilson disease
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