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Comparison of relaxant effects of nifedipine and NS11021 on isolated umbilical arteries of healthy and preeclamptic pregnant women

Baris Karadas,Selin Acar-Sahan,Sercan Kantarci,Nusret Uysal,Ersan Horoz,Tijen Kaya-Temiz

European Journal of Obstetrics & Gynecology and Reproductive Biology（2023）

Cited 2|Views6
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Abstract
Efficacy and potency of NS11021 decreased in HUAs from preeclamptic pregnants. Also, NS11021 is less potent than nifedipine in the preeclampsia group. BKCa channels may have a role in the pathogenesis of preeclampsia, however, further experimental studies are needed to elucidate that.
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Human umbilical artery,Preeclampsia,Nifedipine,NS11021,Ca2+-activated K+ channels
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