Epigenetic Regulation of IPF Fibroblast Phenotype by Glutaminolysis.

Zheyi Xiang,Le Bai,Jennifer Q Zhou,Ricardo R Cevallos, Jonathan R Sanders,Gang Liu,Karen Bernard,Yan Y Sanders

Molecular metabolism（2022）

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摘要

This study indicates that glutamine is critical for supporting pro-fibrotic fibroblast phenotype in lung fibrosis, partially through α-KG-dependent and -independent mechanisms, and supports targeting fibroblast metabolism as a therapeutic method for fibrotic diseases.

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关键词

Col3A1,Glutamine,H3K27me3,PLK1,lung fibrosis,α-KG

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