MiR-19 Family Impairs Adipogenesis by the Downregulation of the PPAR Transcriptional Network
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(2022)
Abstract
microRNAs (miRNAs) are a class of small endogenous RNA that play pivotal roles in both the differentiation and function of adipocytes during the development of obesity. Despite this, only a few miRNA families have been identified as key players in adipogenesis. Here, we show the relevance of the miR-19 family, miR-19a and miR-19b, in lipid accumulation and the expansion of the adipose tissue in obesity. We observed that miR-19s were upregulated in the abdominal subcutaneous adipose tissue (aSAT) of human patients with morbid obesity, whereas after bariatric surgery, their expression was reduced. In vitro experiments identified miR-19a and b as crucial actors in adipogenesis and lipid accumulation. Overall, our results suggest a novel role of the miR-19 family in the regulatory networks underlying adipogenesis and, therefore, adipose tissue dysfunction.
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Key words
adipogenesis,miR-19 family,morbid obesity,adipose tissue,bariatric surgery,PPAR gamma
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