Direct C-H Radiocyanation of Arenes via Organic Photoredox Catalysis
ORGANIC LETTERS(2022)
Abstract
Innovative labeling methods to incorporate the shortlived positron emitter carbon-11(11C) into bioactive molecules are attractive for positron emission tomography (PET) tracer discovery. Herein, we report a direct C-H radiocyanation method that incorporates [11C]cyanide (11CN-) to a series of functional electron-rich arenes via photoredox catalysis. This photoredoxmediated radiocyanation can proceed in an aerobic environment and is not moisture sensitive, which allows for ease of reaction setup and for scalable synthesis of 11C-aryl nitriles from readily available precursors.
MoreTranslated text
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined