Global miRNA expression reveals novel nuclear and mitochondrial interactions in Type 1 diabetes mellitus.

Rafaella Sousa Ferraz, Lucas Cauê Bezerra Santos, Rebecca Lais da-Silva-Cruz,Cintia Helena Braga-da-Silva,Leandro Magalhães,Arthur Ribeiro-Dos-Santos,Amanda Vidal,Tatiana Vinasco-Sandoval,Laís Reis-das-Mercês,Camille Sena-Dos-Santos,Adenilson Leão Pereira, Lilian Souza D'Albuquerque Silva, Franciane T Cunha de Melo, Ana Carolina C Braga de Souza, Valéria S Galvão Leal, Priscila B Barbosa de Figueiredo, João F Abrahão Neto,Lorena Vilhena de Moraes,Gabriela Nascimento de Lemos,Natércia Neves Marques de Queiroz,Karem Miléo Felício,Giovanna C Cavalcante,Ândrea Ribeiro-Dos-Santos,João Soares Felício

Frontiers in endocrinology（2022）

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摘要

Our results demonstrated 41 DE miRNAs that had a great accuracy in discriminating T1DM and control group. Furthermore, we demonstrate the influence of these miRNAs on numerous metabolic pathways, including mitochondrial metabolism. and were highlighted in our results, possibly acting on nuclear and mitochondrial dysfunction and, subsequently, T1DM dysregulation.

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关键词

miRNAs,miRnome,mitochondrial target,nuclear target,type 1 diabetes

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