In patients with primary Sjögren's syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells.

Anneline C Hinrichs,Aike A Kruize,Helen L Leavis,Joel A G van Roon

Frontiers in immunology（2022）

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摘要

Circulating CD161+ and IL-18Rα+ MAIT cell numbers are decreased in pSS patients. Given their enriched CCR9/CXCR5 expression this may facilitate migration to inflamed salivary glands known to overexpress CCL25/CXCL13. Given the pivotal role of IL-7 and IL-21 in inflammation in pSS this indicates a potential role for MAIT cells in driving pSS immunopathology.

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关键词

CCR9/CXCR5 T cells,IL-18Rα,IL-7Rα (CD127),MAIT cells,Sjögren’s syndrome (pSS)

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