Case report: TP53 and RB1 loss may facilitate the transformation from lung adenocarcinoma to small cell lung cancer by expressing neuroendocrine markers.

Jun Li,Bing Wei,Junnan Feng,Xinxin Wu,Yuxi Chang,Yi Wang,Xiuli Yang,Haiyan Zhang,Sile Han,Cuiyun Zhang,Jiawen Zheng,Harry J M Groen,Anke van den Berg,Jie Ma,Hongle Li,Yongjun Guo

Frontiers in endocrinology（2022）

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摘要

We consider the combined presence of MYC amplification with mutations in TP53 and RB1 as drivers of SCLC transformation. Our results highlight the need to systematically evaluate TP53 and RB1 status in LUAD patients to offer a different therapeutic strategy.

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关键词

MYC amplification,TP53 and RB1 loss,lung adenocarcinoma,osimertinib,small cell lung cancer transformation

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