Classification of mild cognitive impairment based on handwriting dynamics and qEEG

Subtle changes in fine motor control and quantitative electroencephalography (qEEG) in patients with mild cognitive impairment (MCI) are important in screening for early dementia in primary care populations. In this study, an automated, non-invasive and rapid detection protocol for mild cognitive impairment based on hand-writing kinetics and quantitative EEG analysis was proposed, and a classification model based on a dual fusion of feature and decision layers was designed for clinical decision-marking. Seventy-nine volunteers (39 healthy elderly controls and 40 patients with mild cognitive impairment) were recruited for this study, and the hand-written data and the EEG signals were performed using a tablet and MUSE under four designed handwriting tasks. Sixty-eight features were extracted from the EEG and handwriting parameters of each test. Features selected from both models were fused using a late feature fusion strategy with a weighted voting strategy for decision making, and classification accuracy was compared using three different classifiers under handwritten features, EEG features and fused features respectively. The results show that the dual fusion model can further improve the classification accuracy, with the highest classification accuracy for the combined features and the best classification result of 96.3% using SVM with RBF kernel as the base classifier. In addition, this not only supports the greater significance of multimodal data for differentiating MCI, but also tests the feasibility of using the portable EEG headband as a measure of EEG in patients with cognitive impairment.